Sesame vs Enhance.MD: Which GLP-1 Clinic Is Better in 2026?
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Short answer
Sesame and Enhance.MD tie at 7.5/10, so it comes down to transparency.
Sesame and Enhance.MD are tied at 7.5/10.
Sesame · from $59/mo care fee on a 12-month plan billed once ($708), medication billed separately
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SSesame
A clinician marketplace for brand-name GLP-1s: you choose the provider, pay a care fee from $59/mo on a 12-month plan billed once, and buy the medication separately, from $149/mo for the Wegovy pill or Foundayo.
from $59/mo care fee on a 12-month plan billed once ($708), medication billed separately
Visit →Is Sesame legit?
One of the few clinics here that names its actual pharmacies and medical groups, publishes every plan length with its billing cadence, and bundles metabolic lab work every six months. But it's priced at the top of this set and it doesn't ship to 10 states.
from $212/mo, billed every 48 weeks
Read Review →Is Enhance.MD legit?Sesame vs Enhance.MD, side by side
| Feature | Sesame | Enhance.MD |
|---|---|---|
| Our score | 7.5/10 | 7.5/10 |
| Starting price | $59/mo care fee on a 12-month plan billed once ($708), medication billed separately | $212/mo, billed every 48 weeks |
| Medication types | Wegovy, Wegovy Pill, Zepbound, Foundayo | compounded semaglutide, compounded tirzepatide, compounded semaglutide + tirzepatide, microdosing |
| Best for | — | — |
| Overall ranking | #14 | #16 |
| Price & Value (25%) | not scored (counted at 7.0) | 6.0 |
| Clinical Oversight (30%) | 8.0 | 8.0 |
| Medication Options (20%) | 8.0 | 8.0 |
| Transparency (25%) | 7.0 | 8.0 |
Sources: Sesame pricing verified on sesamecare.com, Enhance.MD pricing verified on enhance.md
Pros & cons
Sesame
Pros
- + Says next to the price that medication is paid separately, gives a floor for it, and prints the price of each medication on the same page
- + You choose your provider from named clinicians, with video visits, messaging and labs at Quest included in the care fee (except in nine states)
- + Brand-name Wegovy (pen and pill), Zepbound and Foundayo, picked up the same day at your pharmacy or delivered
- + Publishes its refund and cancellation terms and the billing schedule of every plan
Cons
- − Weaker on Transparency (7.0/10 vs 8.0)
Enhance.MD
Pros
- + Publishes the full price grid (all four plan lengths, each with its billing cadence) plus the same price at every dose
- + Names all three partner pharmacies and both medical groups on its own site, which almost nobody in this category does
- + Metabolic lab testing every 6 months and ongoing provider care included in the monthly price, no separate membership fee
Cons
- − Not available in 10 states
The bottom line
After scoring all 61 clinics on our 4-criterion rubric (price & value, clinical oversight, medication options and transparency), Sesame and Enhance.MD are tied at 7.5/10. There is no clear overall winner here, so the right choice comes down to what matters most to you.
Sesame. From $59/mo care fee on a 12-month plan billed once ($708), medication billed separately.
Visit →Enhance.MD. From $212/mo, billed every 48 weeks.
Read Review →Editor's overall pick
Not sold on either? Our highest-rated partner clinic outside this pair is Wellorithm (7.9/10) from $247/mo after month 1. Read the review →
Ready to start GLP-1 weight loss?
Sesame and Enhance.MD are tied on score.
Frequently asked questions
Which is better, Sesame or Enhance.MD?
Sesame and Enhance.MD are tied at 7.5/10. There's no clear overall winner.
How much does Sesame cost vs Enhance.MD?
Sesame is from $59/mo care fee on a 12-month plan billed once ($708), medication billed separately and Enhance.MD is from $212/mo, billed every 48 weeks. Both are typically cash-pay; HSA/FSA funds are often eligible. We run an automated check against each clinic's own live pricing page every week; a price left unconfirmed for 45 days shows as unverified rather than staying marked as current.
What is the difference between Sesame and Enhance.MD?
Sesame (7.5/10, #14 of 61) and Enhance.MD (7.5/10, #16 of 61) are scored independently across our 4 criteria: price & value, clinical oversight, medication options and transparency. See the detailed score breakdown above for the criterion-by-criterion comparison.
Does Sesame or Enhance.MD take insurance?
Insurance terms differ by clinic and by drug: some clinics are cash-pay only, and some help with insurance for brand-name drugs. Each clinic's review says what it publishes. HSA and FSA funds are often eligible. Confirm at checkout.
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How we score: every clinic is rated on 4 weighted criteria from documented evidence. Prices checked weekly. See each review for that clinic's own verification status. Scores are never influenced by affiliate commissions. “Visit” links may be affiliate links that support our work. Educational information only. Not medical advice.