Yucca Health vs Sesame: Which GLP-1 Clinic Is Better in 2026?
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Short answer
Yucca Health wins overall, scoring 7.9/10 vs 7.5/10. Mainly on medication options and transparency.
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Yucca Health
A clean, value-first option: compounded semaglutide from $69/mo on a 12-month plan ($828 billed every 12 months), free 2-day shipping, though it does not name the pharmacy that fills prescriptions. Both GLP-1 injectables, nationwide.
from $69/mo on a 12-month plan, $828 billed every 12 months
Read Review →Is Yucca Health legit?SSesame
A clinician marketplace for brand-name GLP-1s: you choose the provider, pay a care fee from $59/mo on a 12-month plan billed once, and buy the medication separately, from $149/mo for the Wegovy pill or Foundayo.
from $59/mo care fee on a 12-month plan billed once ($708), medication billed separately
Visit →Is Sesame legit?Yucca Health vs Sesame, side by side
| Feature | Yucca Health | Sesame |
|---|---|---|
| Our score | 7.9/10 | 7.5/10 |
| Starting price | $69/mo on a 12-month plan, $828 billed every 12 months | $59/mo care fee on a 12-month plan billed once ($708), medication billed separately |
| Medication types | compounded semaglutide, compounded tirzepatide | Wegovy, Wegovy Pill, Zepbound, Foundayo |
| Best for | Best Value | — |
| Overall ranking | #3 | #14 |
| Price & Value (25%) | 8.5 | not scored (counted at 7.0) |
| Clinical Oversight (30%) | 8.0 | 8.0 |
| Medication Options (20%) | 7.5 | 8.0 |
| Transparency (25%) | 7.5 | 7.0 |
Sources: Yucca Health pricing verified on tryyucca.com, Sesame pricing verified on sesamecare.com
Pros & cons
Yucca Health
Pros
- + $69/mo on a 12-month semaglutide plan, the same price at every dose
- + Free UPS 2-Day Air, kit included, 24/7 care team
- + LegitScript-certified, licensed-provider review in ~24h
Cons
- − Weaker on Medication Options (7.5/10 vs 8.0)
Sesame
Pros
- + Says next to the price that medication is paid separately, gives a floor for it, and prints the price of each medication on the same page
- + You choose your provider from named clinicians, with video visits, messaging and labs at Quest included in the care fee (except in nine states)
- + Brand-name Wegovy (pen and pill), Zepbound and Foundayo, picked up the same day at your pharmacy or delivered
- + Publishes its refund and cancellation terms and the billing schedule of every plan
Cons
- − Weaker on Transparency (7.0/10 vs 7.5)
The bottom line
After scoring all 61 clinics on our 4-criterion rubric (price & value, clinical oversight, medication options and transparency), Yucca Health (7.9/10) comes out ahead of Sesame (7.5/10). But the right choice still depends on what matters most to you.
Yucca Health. From $69/mo on a 12-month plan, $828 billed every 12 months.
Read Review →Sesame. From $59/mo care fee on a 12-month plan billed once ($708), medication billed separately.
Visit →Editor's overall pick
Not sold on either? Our highest-rated partner clinic outside this pair is Wellorithm (7.9/10) from $247/mo after month 1. Read the review →
Ready to start GLP-1 weight loss?
Yucca Health scores higher on our rubric. It is not one of our partners.
Frequently asked questions
Which is better, Yucca Health or Sesame?
Yucca Health scores higher overall (7.9/10 vs 7.5/10) on our rubric.
How much does Yucca Health cost vs Sesame?
Yucca Health is from $69/mo on a 12-month plan, $828 billed every 12 months and Sesame is from $59/mo care fee on a 12-month plan billed once ($708), medication billed separately. Both are typically cash-pay; HSA/FSA funds are often eligible. We run an automated check against each clinic's own live pricing page every week; a price left unconfirmed for 45 days shows as unverified rather than staying marked as current.
What is the difference between Yucca Health and Sesame?
Yucca Health (7.9/10, #3 of 61) and Sesame (7.5/10, #14 of 61) are scored independently across our 4 criteria: price & value, clinical oversight, medication options and transparency. See the detailed score breakdown above for the criterion-by-criterion comparison.
Does Yucca Health or Sesame take insurance?
Insurance terms differ by clinic and by drug: some clinics are cash-pay only, and some help with insurance for brand-name drugs. Each clinic's review says what it publishes. HSA and FSA funds are often eligible. Confirm at checkout.
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How we score: every clinic is rated on 4 weighted criteria from documented evidence. Prices checked weekly. See each review for that clinic's own verification status. Scores are never influenced by affiliate commissions. “Visit” links may be affiliate links that support our work. Educational information only. Not medical advice.