Telos Rx vs Sesame: Which GLP-1 Clinic Is Better in 2026?
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Short answer
Telos Rx wins overall, scoring 7.6/10 vs 7.5/10. Mainly on clinical oversight and medication options.
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Telos Rx
Flat $99/mo compounded semaglutide with no membership fee and no long-term commitment, cancel anytime, plus a genuine oral (needle-free) route for both semaglutide and tirzepatide, which most budget clinics in this range don't offer.
from $99/mo on its lowest-priced plan length ("Your price depends on plan length"; the lengths are not listed)
Read Review →SSesame
A clinician marketplace for brand-name GLP-1s: you choose the provider, pay a care fee from $59/mo on a 12-month plan billed once, and buy the medication separately, from $149/mo for the Wegovy pill or Foundayo.
from $59/mo care fee on a 12-month plan billed once ($708), medication billed separately
Visit →Is Sesame legit?Telos Rx vs Sesame, side by side
| Feature | Telos Rx | Sesame |
|---|---|---|
| Our score | 7.6/10 | 7.5/10 |
| Starting price | $99/mo on its lowest-priced plan length ("Your price depends on plan length"; the lengths are not listed) | $59/mo care fee on a 12-month plan billed once ($708), medication billed separately |
| Medication types | compounded semaglutide, compounded tirzepatide, oral, microdosing | Wegovy, Wegovy Pill, Zepbound, Foundayo |
| Best for | — | — |
| Overall ranking | #13 | #14 |
| Price & Value (25%) | 8.0 | not scored (counted at 7.0) |
| Clinical Oversight (30%) | 7.0 | 8.0 |
| Medication Options (20%) | 8.5 | 8.0 |
| Transparency (25%) | 7.0 | 7.0 |
Sources: Telos Rx pricing source, not currently verified: telosrx.com, Sesame pricing verified on sesamecare.com
Pros & cons
Telos Rx
Pros
- + Compounded semaglutide from $99/mo, tirzepatide from $139/mo. All-inclusive (visit, shipping, dose changes, support all $0)
- + Cancel anytime, no penalties. No 6- or 12-month prepay commitment required for the advertised price
- + Injectable AND oral (needle-free) routes for both semaglutide and tirzepatide, plus a lower-cost microdosing tier
Cons
- − Weaker on Clinical Oversight (7.0/10 vs 8.0)
Sesame
Pros
- + Says next to the price that medication is paid separately, gives a floor for it, and prints the price of each medication on the same page
- + You choose your provider from named clinicians, with video visits, messaging and labs at Quest included in the care fee (except in nine states)
- + Brand-name Wegovy (pen and pill), Zepbound and Foundayo, picked up the same day at your pharmacy or delivered
- + Publishes its refund and cancellation terms and the billing schedule of every plan
Cons
- − Weaker on Medication Options (8.0/10 vs 8.5)
The bottom line
After scoring all 61 clinics on our 4-criterion rubric (price & value, clinical oversight, medication options and transparency), Telos Rx (7.6/10) comes out ahead of Sesame (7.5/10). But the right choice still depends on what matters most to you.
Telos Rx. From $99/mo on its lowest-priced plan length ("Your price depends on plan length"; the lengths are not listed).
Read Review →Sesame. From $59/mo care fee on a 12-month plan billed once ($708), medication billed separately.
Visit →Editor's overall pick
Not sold on either? Our highest-rated partner clinic outside this pair is Wellorithm (7.9/10) from $247/mo after month 1. Read the review →
Ready to start GLP-1 weight loss?
Telos Rx scores higher on our rubric. It is not one of our partners.
Frequently asked questions
Which is better, Telos Rx or Sesame?
Telos Rx scores higher overall (7.6/10 vs 7.5/10) on our rubric.
How much does Telos Rx cost vs Sesame?
Telos Rx is from $99/mo on its lowest-priced plan length ("Your price depends on plan length"; the lengths are not listed) and Sesame is from $59/mo care fee on a 12-month plan billed once ($708), medication billed separately. Both are typically cash-pay; HSA/FSA funds are often eligible. We run an automated check against each clinic's own live pricing page every week; a price left unconfirmed for 45 days shows as unverified rather than staying marked as current.
What is the difference between Telos Rx and Sesame?
Telos Rx (7.6/10, #13 of 61) and Sesame (7.5/10, #14 of 61) are scored independently across our 4 criteria: price & value, clinical oversight, medication options and transparency. See the detailed score breakdown above for the criterion-by-criterion comparison.
Does Telos Rx or Sesame take insurance?
Insurance terms differ by clinic and by drug: some clinics are cash-pay only, and some help with insurance for brand-name drugs. Each clinic's review says what it publishes. HSA and FSA funds are often eligible. Confirm at checkout.
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How we score: every clinic is rated on 4 weighted criteria from documented evidence. Prices checked weekly. See each review for that clinic's own verification status. Scores are never influenced by affiliate commissions. “Visit” links may be affiliate links that support our work. Educational information only. Not medical advice.