RxSpan MD vs Sesame Care: Which GLP-1 Clinic Is Better in 2026?
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Short answer
RxSpan MD wins overall, scoring 7.3/10 vs 7.1/10 — mainly on medication options and price & value. If price is your priority, Sesame Care is cheaper at $99/mo.
RxSpan MD wins overall, scoring 7.3/10 vs 7.1/10. If price is your priority, Sesame Care is cheaper at $99/mo.
RxSpan MD
Both GLP-1 molecules in both routes plus three real brand names, and the most rigorously sourced medication-comparison page of any clinic we track — from a practice that publishes neither its pharmacy, nor the states it ships to, nor any refund terms behind a $2,327 upfront charge.
from $194/mo
Visit RxSpan MDSesame Care
A pay-per-visit telehealth marketplace rather than a subscription clinic — a $99/28-day membership covers ongoing care, with compounded semaglutide available from around $249/mo and brand-name Wegovy options through partner pharmacies.
from $99/mo
Visit Sesame CareRxSpan MD vs Sesame Care, side by side
| Feature | RxSpan MD | Sesame Care |
|---|---|---|
| Our score | 7.3/10 | 7.1/10 |
| Starting price | $194/mo | $99/mo |
| Medication types | compounded semaglutide, compounded tirzepatide, oral semaglutide capsules, oral tirzepatide capsules, brand-name Ozempic/Wegovy/Zepbound | compounded semaglutide, brand-name semaglutide (Wegovy) |
| Best for | — | — |
| Overall ranking | #18 | #25 |
| Price & Value (25%) | 6.0 | 7.0 |
| Clinical Oversight (30%) | 8.0 | 7.0 |
| Medication Options (20%) | 9.0 | 7.5 |
| Transparency (25%) | 6.5 | 7.0 |
Sources: RxSpan MD pricing verified on rxspanmd.com
Pros & cons
RxSpan MD
Pros
- + Semaglutide and tirzepatide in injection AND oral-capsule form, plus cash-pay Ozempic, Wegovy and Zepbound
- + Founding physician named and independently verifiable — Dr. John Diaz, MD, FACS, board-certified by the American Board of Plastic Surgery
- + Publishes the pre-discount rate next to the promo rate, and the full plan grid with the actual upfront dollar amount for each term
Cons
- − Weaker on Price & Value (6.0/10)
- − Weaker on Transparency (6.5/10)
- − Weaker on Clinical Oversight (8.0/10)
Sesame Care
Pros
- + Marketplace model: pay for care access ($99/28 days) without a long-term program lock-in
- + Offers both compounded and brand-name Wegovy paths
- + Backed by a large, well-funded telehealth marketplace with broad physician network
Cons
- − Weaker on Price & Value (7.0/10)
- − Weaker on Clinical Oversight (7.0/10)
- − Weaker on Transparency (7.0/10)
The bottom line
After scoring all 38 clinics on our 4-criterion rubric (price & value, clinical oversight, medication options and transparency), RxSpan MD (7.3/10) comes out ahead of Sesame Care (7.1/10) — but the right choice still depends on what matters most to you.
Choose RxSpan MD if you want this option — from $194/mo.
Visit RxSpan MD →Choose Sesame Care if you want this option — from $99/mo.
Visit Sesame Care →Editor's overall pick
Not sold on either? Our highest-rated clinic overall is Wellorithm (8.3/10) from $147/mo — read the review →
Ready to start GLP-1 weight loss?
Our verdict for this matchup is RxSpan MD.
Frequently asked questions
Which is better, RxSpan MD or Sesame Care?
RxSpan MD scores higher overall (7.3/10 vs 7.1/10) and is our recommended pick for most people. If price is the priority, Sesame Care starts at $99/mo.
How much does RxSpan MD cost vs Sesame Care?
RxSpan MD is from $194/mo and Sesame Care is from $99/mo. Both are typically cash-pay; HSA/FSA funds are often eligible. We run an automated check against each clinic's own live pricing page every week; a price left unconfirmed for 45 days shows as unverified rather than staying marked as current.
What is the difference between RxSpan MD and Sesame Care?
RxSpan MD (7.3/10, #18 of 38) and Sesame Care (7.1/10, #25 of 38) are scored independently across our 4 criteria: price & value, clinical oversight, medication options and transparency. See the detailed score breakdown above for the criterion-by-criterion comparison.
Does RxSpan MD or Sesame Care take insurance?
Neither RxSpan MD nor Sesame Care typically accepts insurance for GLP-1 weight-loss treatment. Both operate on a cash-pay model, though HSA and FSA funds are often eligible. Confirm at checkout.
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How we score: every clinic is rated on five weighted criteria from documented evidence. Prices checked weekly— see each review for that clinic's own verification status. Scores are never influenced by affiliate commissions. “Visit”/“Try” links may be affiliate links that support our work. Educational information only — not medical advice.