Synergy RX vs Sesame Care: Which GLP-1 Clinic Is Better in 2026?
Synergy RX wins overall, scoring 7.5/10 vs 7.2/10. If price is your priority, Sesame Care is cheaper at $99/mo.
Synergy RX
The high-touch option: a dedicated care team and unlimited 24/7 support guiding every step toward a 1–2 lb/week pace — premium support at the same price as standard plans.
from $199/mo
Visit Synergy RXSesame Care
A pay-per-visit telehealth marketplace rather than a subscription clinic — a $99/28-day membership covers ongoing care, with compounded semaglutide available from around $249/mo and brand-name Wegovy options through partner pharmacies.
from $99/mo
Visit Sesame CareSynergy RX vs Sesame Care, side by side
| Feature | Synergy RX | Sesame Care |
|---|---|---|
| Our score | 7.5/10 | 7.2/10 |
| Starting price | $199/mo | $99/mo |
| Medication types | compounded semaglutide, compounded tirzepatide | compounded semaglutide, brand-name semaglutide (Wegovy) |
| Best for | Best Support | — |
| Overall ranking | #13 | #18 |
| Price & Value (25%) | 7.0 | 7.0 |
| Clinical Oversight (25%) | 8.5 | 7.0 |
| Medication Options (20%) | 7.0 | 7.5 |
| User Experience (15%) | 8.5 | 7.5 |
| Transparency (15%) | 6.5 | 7.0 |
Pros & cons
Synergy RX
Pros
- + Unlimited 24/7 support from a dedicated care team
- + Hand-selected providers, guided every step
- + Structured plan targeting steady, safe loss
Cons
- − Weaker on Transparency (6.5/10)
- − Weaker on Price & Value (7.0/10)
- − Weaker on Medication Options (7.0/10)
Sesame Care
Pros
- + Marketplace model: pay for care access ($99/28 days) without a long-term program lock-in
- + Offers both compounded and brand-name Wegovy paths
- + Backed by a large, well-funded telehealth marketplace with broad physician network
Cons
- − Weaker on Price & Value (7.0/10)
- − Weaker on Clinical Oversight (7.0/10)
- − Weaker on Transparency (7.0/10)
The bottom line
After scoring all 22 clinics on price, clinical oversight, medication options, experience and transparency, Synergy RX (7.5/10) comes out ahead of Sesame Care (7.2/10) — but the right choice depends on what matters most to you.
Choose Synergy RX if you want best support — from $199/mo.
Visit Synergy RX →Choose Sesame Care if you want this option — from $99/mo.
Visit Sesame Care →Editor's overall pick
Not sold on either? Our highest-rated clinic overall is Gala Health (8.3/10) from $149/mo — read the review →
Ready to start GLP-1 weight loss?
Our verdict for this matchup is Synergy RX.
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How we score: every clinic is rated on five weighted criteria from documented evidence, re-verified monthly. Scores are never influenced by affiliate commissions. “Visit”/“Try” links may be affiliate links that support our work. Educational information only — not medical advice.