Sesame Care vs HumeCare+: Which GLP-1 Clinic Is Better in 2026?
Summarize this page with
Short answer
Sesame Care wins overall, scoring 7.1/10 vs 6.9/10 — mainly on transparency and clinical oversight.
Sesame Care wins overall, scoring 7.1/10 vs 6.9/10.
Sesame Care
A telehealth marketplace with its own weight-loss subscription — Success by Sesame from $59/mo on the annual plan ($99 month-to-month) covers ongoing care, with medication billed separately from around $249/mo and brand-name Wegovy options through partner pharmacies.
from $59/mo
Visit Sesame CareHumeCare+
A $199/month GLP-1 protocol that bundles a body-composition scanner and weekly physician-read scans — the most monitoring anyone here describes, sold by a clinic whose Trustpilot profile was removed for breaking Trustpilot's guidelines while its pages still display a Trustpilot score.
from $199/mo
Visit HumeCare+Sesame Care vs HumeCare+, side by side
| Feature | Sesame Care | HumeCare+ |
|---|---|---|
| Our score | 7.1/10 | 6.9/10 |
| Starting price | $59/mo | $199/mo |
| Medication types | compounded semaglutide, brand-name semaglutide (Wegovy) | compounded semaglutide, compounded tirzepatide, GLP-1 microdosing, oral GLP-1 protocol |
| Best for | — | — |
| Overall ranking | #27 | #30 |
| Price & Value (25%) | 7.0 | 7.0 |
| Clinical Oversight (30%) | 7.0 | 7.5 |
| Medication Options (20%) | 7.5 | 8.0 |
| Transparency (25%) | 7.0 | 5.0 |
Sources: Sesame Care pricing verified on sesamecare.com, HumeCare+ pricing verified on humecare.com
Pros & cons
Sesame Care
Pros
- + Four published commitment tiers — $59/mo annual down from $99/mo month-to-month
- + Offers both compounded and brand-name Wegovy paths
- + Backed by a large, well-funded telehealth marketplace with broad physician network
Cons
- − Weaker on Price & Value (7.0/10)
- − Weaker on Clinical Oversight (7.0/10)
- − Weaker on Transparency (7.0/10)
HumeCare+
Pros
- + $199/mo billed monthly with cancellation available any time — no prepay, no lock-in, medication included, and HSA/FSA accepted
- + Publishes a real states-served exclusion list (not available in Alabama, Louisiana or Mississippi) and a numeric eligibility threshold (BMI 25+) — most clinics here publish neither
- + Describes the most specific monitoring cadence in this ranking: weekly body-composition scans on an included device, read by a physician who adjusts the dose against them
Cons
- − Not available in 3 states
- − Weaker on Transparency (5.0/10)
- − Weaker on Price & Value (7.0/10)
The bottom line
After scoring all 42 clinics on our 4-criterion rubric (price & value, clinical oversight, medication options and transparency), Sesame Care (7.1/10) comes out ahead of HumeCare+ (6.9/10) — but the right choice still depends on what matters most to you.
Choose Sesame Care if you want this option — from $59/mo.
Visit Sesame Care →Choose HumeCare+ if you want this option — from $199/mo.
Visit HumeCare+ →Editor's overall pick
Not sold on either? Our highest-rated clinic overall is Wellorithm (8.3/10) from $147/mo — read the review →
Ready to start GLP-1 weight loss?
Our verdict for this matchup is Sesame Care.
Frequently asked questions
Which is better, Sesame Care or HumeCare+?
Sesame Care scores higher overall (7.1/10 vs 6.9/10) and is our recommended pick for most people. Sesame Care also has the lower starting price at $59/mo.
How much does Sesame Care cost vs HumeCare+?
Sesame Care is from $59/mo and HumeCare+ is from $199/mo. Both are typically cash-pay; HSA/FSA funds are often eligible. We run an automated check against each clinic's own live pricing page every week; a price left unconfirmed for 45 days shows as unverified rather than staying marked as current.
What is the difference between Sesame Care and HumeCare+?
Sesame Care (7.1/10, #27 of 42) and HumeCare+ (6.9/10, #30 of 42) are scored independently across our 4 criteria: price & value, clinical oversight, medication options and transparency. See the detailed score breakdown above for the criterion-by-criterion comparison.
Does Sesame Care or HumeCare+ take insurance?
Neither Sesame Care nor HumeCare+ typically accepts insurance for GLP-1 weight-loss treatment. Both operate on a cash-pay model, though HSA and FSA funds are often eligible. Confirm at checkout.
Related comparisons
Top picks
We email you when a price we track changes.
No spam, no daily digest — just the clinics you're comparing, when their verified price moves.
How we score: every clinic is rated on five weighted criteria from documented evidence. Prices checked weekly— see each review for that clinic's own verification status. Scores are never influenced by affiliate commissions. “Visit”/“Try” links may be affiliate links that support our work. Educational information only — not medical advice.