Yucca Health vs Calibrate: Which GLP-1 Clinic Is Better in 2026?
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Short answer
Yucca Health wins overall, scoring 7.9/10 vs 7.0/10. Mainly on transparency and medication options.
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Yucca Health
A clean, value-first option: compounded semaglutide from $69/mo on a 12-month plan ($828 billed every 12 months), free 2-day shipping, though it does not name the pharmacy that fills prescriptions. Both GLP-1 injectables, nationwide.
from $69/mo on a 12-month plan, $828 billed every 12 months
Read Review →Is Yucca Health legit?
Calibrate
A coaching-first GLP-1 program that prescribes only brand-name medication through your commercial insurance. The $199/mo is a membership on a locked 3-month minimum, with medication and labs billed separately, and it does not accept uninsured patients or Medicare, Medicaid, Tricare or Kaiser members.
from $199/mo membership, 3-month minimum ($597), medication and labs billed through your insurance
Read Review →Yucca Health vs Calibrate, side by side
| Feature | Yucca Health | Calibrate |
|---|---|---|
| Our score | 7.9/10 | 7.0/10 |
| Starting price | $69/mo on a 12-month plan, $828 billed every 12 months | $199/mo membership, 3-month minimum ($597), medication and labs billed through your insurance |
| Medication types | compounded semaglutide, compounded tirzepatide | brand-name Zepbound, brand-name Wegovy (injection or pill), brand-name Foundayo (oral orforglipron), brand-name Mounjaro, brand-name Ozempic, brand-name Saxenda, brand-name Trulicity, brand-name Rybelsus |
| Best for | Best Value | — |
| Overall ranking | #3 | #37 |
| Price & Value (25%) | 8.5 | not scored (counted at 6.0) |
| Clinical Oversight (30%) | 8.0 | 8.0 |
| Medication Options (20%) | 7.5 | 8.0 |
| Transparency (25%) | 7.5 | 6.0 |
Sources: Yucca Health pricing verified on tryyucca.com, Calibrate pricing verified on joincalibrate.com
Pros & cons
Yucca Health
Pros
- + $69/mo on a 12-month semaglutide plan, the same price at every dose
- + Free UPS 2-Day Air, kit included, 24/7 care team
- + LegitScript-certified, licensed-provider review in ~24h
Cons
- − Weaker on Medication Options (7.5/10 vs 8.0)
Calibrate
Pros
- + Brand-name only, and says so plainly: its own FAQ states it does not prescribe compounded GLP-1s because they are not FDA-approved
- + Live 1:1 video visit with a clinician who reviews six named lab tests before prescribing, plus coaching every two weeks and medical check-ins through the app
- + Publishes its full membership terms, cancellation policy and money-back terms (50% back if you lose under 10% after 12 consecutive months, with conditions)
Cons
- − Weaker on Transparency (6.0/10 vs 7.5)
The bottom line
After scoring all 61 clinics on our 4-criterion rubric (price & value, clinical oversight, medication options and transparency), Yucca Health (7.9/10) comes out ahead of Calibrate (7.0/10). But the right choice still depends on what matters most to you.
Yucca Health. From $69/mo on a 12-month plan, $828 billed every 12 months.
Read Review →Calibrate. From $199/mo membership, 3-month minimum ($597), medication and labs billed through your insurance.
Read Review →Editor's overall pick
Not sold on either? Our highest-rated partner clinic outside this pair is Wellorithm (7.9/10) from $247/mo after month 1. Read the review →
Ready to start GLP-1 weight loss?
Yucca Health scores higher on our rubric. It is not one of our partners.
Frequently asked questions
Which is better, Yucca Health or Calibrate?
Yucca Health scores higher overall (7.9/10 vs 7.0/10) on our rubric.
How much does Yucca Health cost vs Calibrate?
Yucca Health is from $69/mo on a 12-month plan, $828 billed every 12 months and Calibrate is from $199/mo membership, 3-month minimum ($597), medication and labs billed through your insurance. Both are typically cash-pay; HSA/FSA funds are often eligible. We run an automated check against each clinic's own live pricing page every week; a price left unconfirmed for 45 days shows as unverified rather than staying marked as current.
What is the difference between Yucca Health and Calibrate?
Yucca Health (7.9/10, #3 of 61) and Calibrate (7.0/10, #37 of 61) are scored independently across our 4 criteria: price & value, clinical oversight, medication options and transparency. See the detailed score breakdown above for the criterion-by-criterion comparison.
Does Yucca Health or Calibrate take insurance?
Insurance terms differ by clinic and by drug: some clinics are cash-pay only, and some help with insurance for brand-name drugs. Each clinic's review says what it publishes. HSA and FSA funds are often eligible. Confirm at checkout.
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How we score: every clinic is rated on 4 weighted criteria from documented evidence. Prices checked weekly. See each review for that clinic's own verification status. Scores are never influenced by affiliate commissions. “Visit” links may be affiliate links that support our work. Educational information only. Not medical advice.