RxSpan MD vs He & She MD: Which GLP-1 Clinic Is Better in 2026?
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Short answer
RxSpan MD and He & She MD tie at 7.3/10, so it comes down to price and transparency. He & She MD is cheaper at $99/mo on a $1,188 prepaid year.
RxSpan MD and He & She MD are tied at 7.3/10. If price is your priority, He & She MD is cheaper at $99/mo on a $1,188 prepaid year.
RxSpan MD · from $175/mo on a $2,094 upfront 12-month plan
Both GLP-1 molecules in both routes plus three real brand names, and the most rigorously sourced medication-comparison page of any clinic we track. From a practice that publishes neither its pharmacy, nor the states it ships to, nor any refund terms behind a $2,094 upfront charge.
from $175/mo on a $2,094 upfront 12-month plan
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He & She MD
Two GLP-1 molecules in both injection and oral form plus cash-pay Ozempic and Zepbound, from $99/mo on the annual plan. From a site that publishes two contradictory price grids for the same medication and advertises a 4.9 rating on a Trustpilot profile holding zero reviews.
from $99/mo on a $1,188 prepaid year
Read Review →RxSpan MD vs He & She MD, side by side
| Feature | RxSpan MD | He & She MD |
|---|---|---|
| Our score | 7.3/10 | 7.3/10 |
| Starting price | $175/mo on a $2,094 upfront 12-month plan | $99/mo on a $1,188 prepaid year |
| Medication types | compounded semaglutide, compounded tirzepatide, oral semaglutide capsules, oral tirzepatide capsules, brand-name Ozempic/Wegovy/Zepbound | compounded semaglutide, compounded tirzepatide, oral semaglutide, oral tirzepatide, brand-name Ozempic/Zepbound |
| Best for | — | — |
| Overall ranking | #20 | #22 |
| Price & Value (25%) | 6.0 | 7.5 |
| Clinical Oversight (30%) | 8.0 | 7.5 |
| Medication Options (20%) | 9.0 | 9.0 |
| Transparency (25%) | 6.5 | 5.5 |
Sources: RxSpan MD pricing verified on rxspanmd.com, He & She MD pricing verified on heandshemd.com
Pros & cons
RxSpan MD
Pros
- + Semaglutide and tirzepatide in injection AND oral-capsule form, plus cash-pay Ozempic, Wegovy and Zepbound
- + Founding physician named and independently verifiable. Dr. John Diaz, MD, FACS, board-certified by the American Board of Plastic Surgery
- + Publishes the pre-discount rate next to the promo rate, and the full plan grid with the actual upfront dollar amount for each term
Cons
- − Weaker on Price & Value (6.0/10)
- − Weaker on Transparency (6.5/10)
- − Weaker on Clinical Oversight (8.0/10)
He & She MD
Pros
- + $99/mo on the annual plan, with the $1,188 upfront total printed on the page
- + Publishes a real states-served exclusion list (no shipping to New Jersey, Mississippi, Alaska or Hawaii) which most clinics here do not publish at all
- + Names the medical group that treats you (Beluga Health, P.A.) in its Terms of Service, and offers both molecules in both injection and oral form plus brand-name Ozempic and Zepbound
Cons
- − Not available in 4 states
- − Weaker on Transparency (5.5/10)
- − Weaker on Price & Value (7.5/10)
The bottom line
After scoring all 56 clinics on our 4-criterion rubric (price & value, clinical oversight, medication options and transparency), RxSpan MD and He & She MD are tied at 7.3/10. There is no clear overall winner here, so the right choice comes down to what matters most to you.
Choose RxSpan MD if you want this option. From $175/mo on a $2,094 upfront 12-month plan.
Visit →Choose He & She MD if you want this option. From $99/mo on a $1,188 prepaid year.
Read Review →Editor's overall pick
Not sold on either? Our highest-rated clinic overall is Wellorithm (7.9/10) from $247/mo after month 1. Read the review →
Ready to start GLP-1 weight loss?
RxSpan MD and He & She MD are tied on score. Either is a solid choice.
Frequently asked questions
Which is better, RxSpan MD or He & She MD?
RxSpan MD and He & She MD are tied at 7.3/10. There's no clear overall winner. If price is the deciding factor, He & She MD starts at $99/mo on a $1,188 prepaid year.
How much does RxSpan MD cost vs He & She MD?
RxSpan MD is from $175/mo on a $2,094 upfront 12-month plan and He & She MD is from $99/mo on a $1,188 prepaid year. Both are typically cash-pay; HSA/FSA funds are often eligible. We run an automated check against each clinic's own live pricing page every week; a price left unconfirmed for 45 days shows as unverified rather than staying marked as current.
What is the difference between RxSpan MD and He & She MD?
RxSpan MD (7.3/10, #20 of 56) and He & She MD (7.3/10, #22 of 56) are scored independently across our 4 criteria: price & value, clinical oversight, medication options and transparency. See the detailed score breakdown above for the criterion-by-criterion comparison.
Does RxSpan MD or He & She MD take insurance?
Neither RxSpan MD nor He & She MD typically accepts insurance for GLP-1 weight-loss treatment. Both operate on a cash-pay model, though HSA and FSA funds are often eligible. Confirm at checkout.
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How we score: every clinic is rated on 4 weighted criteria from documented evidence. Prices checked weekly. See each review for that clinic's own verification status. Scores are never influenced by affiliate commissions. “Visit” links may be affiliate links that support our work. Educational information only. Not medical advice.