Yucca Health vs RxSpan MD: Which GLP-1 Clinic Is Better in 2026?
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Short answer
Yucca Health wins overall, scoring 7.9/10 vs 7.3/10. Mainly on price & value and medication options.
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Yucca Health
A clean, value-first option: compounded semaglutide from $69/mo on a 12-month plan ($828 billed every 12 months), free 2-day shipping, though it does not name the pharmacy that fills prescriptions. Both GLP-1 injectables, nationwide.
from $69/mo on a 12-month plan, $828 billed every 12 months
Read Review →Is Yucca Health legit?
Both GLP-1 molecules in both routes plus three real brand names, and the most rigorously sourced medication-comparison page of any clinic we track. From a practice that publishes neither its pharmacy, nor the states it ships to, nor any refund terms behind a $2,094 upfront charge.
from $175/mo on a $2,094 upfront 12-month plan
Visit →Yucca Health vs RxSpan MD, side by side
| Feature | Yucca Health | RxSpan MD |
|---|---|---|
| Our score | 7.9/10 | 7.3/10 |
| Starting price | $69/mo on a 12-month plan, $828 billed every 12 months | $175/mo on a $2,094 upfront 12-month plan |
| Medication types | compounded semaglutide, compounded tirzepatide | compounded semaglutide, compounded tirzepatide, oral semaglutide capsules, oral tirzepatide capsules, brand-name Ozempic/Wegovy/Zepbound |
| Best for | Best Value | — |
| Overall ranking | #3 | #21 |
| Price & Value (25%) | 8.5 | 6.0 |
| Clinical Oversight (30%) | 8.0 | 8.0 |
| Medication Options (20%) | 7.5 | 9.0 |
| Transparency (25%) | 7.5 | 6.5 |
Sources: Yucca Health pricing verified on tryyucca.com, RxSpan MD pricing verified on rxspanmd.com
Pros & cons
Yucca Health
Pros
- + $69/mo on a 12-month semaglutide plan, the same price at every dose
- + Free UPS 2-Day Air, kit included, 24/7 care team
- + LegitScript-certified, licensed-provider review in ~24h
Cons
- − Weaker on Medication Options (7.5/10 vs 9.0)
RxSpan MD
Pros
- + Semaglutide and tirzepatide in injection AND oral-capsule form, plus cash-pay Ozempic, Wegovy and Zepbound
- + Founding physician named and independently verifiable. Dr. John Diaz, MD, FACS, board-certified by the American Board of Plastic Surgery
- + Publishes the pre-discount rate next to the promo rate, and the full plan grid with the actual upfront dollar amount for each term
Cons
- − Weaker on Price & Value (6.0/10 vs 8.5)
- − Weaker on Transparency (6.5/10 vs 7.5)
The bottom line
After scoring all 61 clinics on our 4-criterion rubric (price & value, clinical oversight, medication options and transparency), Yucca Health (7.9/10) comes out ahead of RxSpan MD (7.3/10). But the right choice still depends on what matters most to you.
Yucca Health. From $69/mo on a 12-month plan, $828 billed every 12 months.
Read Review →RxSpan MD. From $175/mo on a $2,094 upfront 12-month plan.
Visit →Editor's overall pick
Not sold on either? Our highest-rated partner clinic outside this pair is Wellorithm (7.9/10) from $247/mo after month 1. Read the review →
Ready to start GLP-1 weight loss?
Yucca Health scores higher on our rubric. It is not one of our partners.
Frequently asked questions
Which is better, Yucca Health or RxSpan MD?
Yucca Health scores higher overall (7.9/10 vs 7.3/10) on our rubric.
How much does Yucca Health cost vs RxSpan MD?
Yucca Health is from $69/mo on a 12-month plan, $828 billed every 12 months and RxSpan MD is from $175/mo on a $2,094 upfront 12-month plan. Both are typically cash-pay; HSA/FSA funds are often eligible. We run an automated check against each clinic's own live pricing page every week; a price left unconfirmed for 45 days shows as unverified rather than staying marked as current.
What is the difference between Yucca Health and RxSpan MD?
Yucca Health (7.9/10, #3 of 61) and RxSpan MD (7.3/10, #21 of 61) are scored independently across our 4 criteria: price & value, clinical oversight, medication options and transparency. See the detailed score breakdown above for the criterion-by-criterion comparison.
Does Yucca Health or RxSpan MD take insurance?
Insurance terms differ by clinic and by drug: some clinics are cash-pay only, and some help with insurance for brand-name drugs. Each clinic's review says what it publishes. HSA and FSA funds are often eligible. Confirm at checkout.
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How we score: every clinic is rated on 4 weighted criteria from documented evidence. Prices checked weekly. See each review for that clinic's own verification status. Scores are never influenced by affiliate commissions. “Visit” links may be affiliate links that support our work. Educational information only. Not medical advice.