Yucca Health vs RxSpan MD: Which GLP-1 Clinic Is Better in 2026?
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Short answer
Yucca Health wins overall, scoring 7.5/10 vs 7.3/10 — mainly on medication options and price & value.
Yucca Health wins overall, scoring 7.5/10 vs 7.3/10.
Yucca Health
A clean, value-first option: compounded semaglutide from $125/mo (6-month plan), free 2-day shipping and a LegitScript-certified pharmacy behind it — both GLP-1 injectables, nationwide.
from $125/mo
Visit Yucca HealthRxSpan MD
Both GLP-1 molecules in both routes plus three real brand names, and the most rigorously sourced medication-comparison page of any clinic we track — from a practice that publishes neither its pharmacy, nor the states it ships to, nor any refund terms behind a $2,327 upfront charge.
from $194/mo
Visit RxSpan MDYucca Health vs RxSpan MD, side by side
| Feature | Yucca Health | RxSpan MD |
|---|---|---|
| Our score | 7.5/10 | 7.3/10 |
| Starting price | $125/mo | $194/mo |
| Medication types | compounded semaglutide, compounded tirzepatide | compounded semaglutide, compounded tirzepatide, oral semaglutide capsules, oral tirzepatide capsules, brand-name Ozempic/Wegovy/Zepbound |
| Best for | Best Value | — |
| Overall ranking | #13 | #18 |
| Price & Value (25%) | 7.0 | 6.0 |
| Clinical Oversight (30%) | 8.0 | 8.0 |
| Medication Options (20%) | 7.5 | 9.0 |
| Transparency (25%) | 7.5 | 6.5 |
Sources: Yucca Health pricing verified on tryyucca.com, RxSpan MD pricing verified on rxspanmd.com
Pros & cons
Yucca Health
Pros
- + Low $125/mo entry on a 6-month semaglutide plan
- + Free UPS 2-Day Air, kit included, 24/7 care team
- + LegitScript-certified, licensed-provider review in ~24h
Cons
- − Weaker on Price & Value (7.0/10)
- − Weaker on Medication Options (7.5/10)
- − Weaker on Transparency (7.5/10)
RxSpan MD
Pros
- + Semaglutide and tirzepatide in injection AND oral-capsule form, plus cash-pay Ozempic, Wegovy and Zepbound
- + Founding physician named and independently verifiable — Dr. John Diaz, MD, FACS, board-certified by the American Board of Plastic Surgery
- + Publishes the pre-discount rate next to the promo rate, and the full plan grid with the actual upfront dollar amount for each term
Cons
- − Weaker on Price & Value (6.0/10)
- − Weaker on Transparency (6.5/10)
- − Weaker on Clinical Oversight (8.0/10)
The bottom line
After scoring all 38 clinics on our 4-criterion rubric (price & value, clinical oversight, medication options and transparency), Yucca Health (7.5/10) comes out ahead of RxSpan MD (7.3/10) — but the right choice still depends on what matters most to you.
Choose Yucca Health if you want best value — from $125/mo.
Visit Yucca Health →Choose RxSpan MD if you want this option — from $194/mo.
Visit RxSpan MD →Editor's overall pick
Not sold on either? Our highest-rated clinic overall is Wellorithm (8.3/10) from $147/mo — read the review →
Ready to start GLP-1 weight loss?
Our verdict for this matchup is Yucca Health.
Frequently asked questions
Which is better, Yucca Health or RxSpan MD?
Yucca Health scores higher overall (7.5/10 vs 7.3/10) and is our recommended pick for most people. Yucca Health also has the lower starting price at $125/mo.
How much does Yucca Health cost vs RxSpan MD?
Yucca Health is from $125/mo and RxSpan MD is from $194/mo. Both are typically cash-pay; HSA/FSA funds are often eligible. We run an automated check against each clinic's own live pricing page every week; a price left unconfirmed for 45 days shows as unverified rather than staying marked as current.
What is the difference between Yucca Health and RxSpan MD?
Yucca Health (7.5/10, #13 of 38) and RxSpan MD (7.3/10, #18 of 38) are scored independently across our 4 criteria: price & value, clinical oversight, medication options and transparency. See the detailed score breakdown above for the criterion-by-criterion comparison.
Does Yucca Health or RxSpan MD take insurance?
Neither Yucca Health nor RxSpan MD typically accepts insurance for GLP-1 weight-loss treatment. Both operate on a cash-pay model, though HSA and FSA funds are often eligible. Confirm at checkout.
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How we score: every clinic is rated on five weighted criteria from documented evidence. Prices checked weekly— see each review for that clinic's own verification status. Scores are never influenced by affiliate commissions. “Visit”/“Try” links may be affiliate links that support our work. Educational information only — not medical advice.