Synergy RX vs He & She MD: Which GLP-1 Clinic Is Better in 2026?
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Short answer
Synergy RX wins overall, scoring 7.5/10 vs 7.3/10 — mainly on medication options and transparency. If price is your priority, He & She MD is cheaper at $99/mo.
Synergy RX wins overall, scoring 7.5/10 vs 7.3/10. If price is your priority, He & She MD is cheaper at $99/mo.
Synergy RX
The high-touch option: a dedicated care team and unlimited 24/7 support guiding every step toward a 1-2 lb/week pace, with compounded semaglutide published at $199/mo on its own products page.
from $199/mo
Visit Synergy RXHe & She MD
Two GLP-1 molecules in both injection and oral form plus cash-pay Ozempic and Zepbound, at the joint-lowest entry rate we track — from a site that publishes two contradictory price grids for the same medication and advertises a 4.9 rating on a Trustpilot profile holding zero reviews.
from $99/mo
Visit He & She MDSynergy RX vs He & She MD, side by side
| Feature | Synergy RX | He & She MD |
|---|---|---|
| Our score | 7.5/10 | 7.3/10 |
| Starting price | $199/mo | $99/mo |
| Medication types | compounded semaglutide, compounded tirzepatide | compounded semaglutide, compounded tirzepatide, oral semaglutide, oral tirzepatide, brand-name Ozempic/Zepbound |
| Best for | Best Support | — |
| Overall ranking | #14 | #22 |
| Price & Value (25%) | 7.0 | 7.5 |
| Clinical Oversight (30%) | 8.5 | 7.5 |
| Medication Options (20%) | 7.0 | 9.0 |
| Transparency (25%) | 7.0 | 5.5 |
Sources: Synergy RX pricing verified on synergyrx.co, He & She MD pricing verified on heandshemd.com
Pros & cons
Synergy RX
Pros
- + Unlimited 24/7 support from a dedicated care team
- + Hand-selected providers, guided every step
- + Structured plan targeting steady, safe loss
Cons
- − Weaker on Price & Value (7.0/10)
- − Weaker on Medication Options (7.0/10)
- − Weaker on Transparency (7.0/10)
He & She MD
Pros
- + $99/mo on the annual plan ties HealthRX for the lowest recurring GLP-1 rate in this ranking, with the $1,188 upfront total printed on the page
- + Publishes a real states-served exclusion list — no shipping to New Jersey, Mississippi, Alaska or Hawaii — which most clinics here do not publish at all
- + Names the medical group that treats you (Beluga Health, P.A.) in its Terms of Service, and offers both molecules in both injection and oral form plus brand-name Ozempic and Zepbound
Cons
- − Not available in 4 states
- − Weaker on Transparency (5.5/10)
- − Weaker on Price & Value (7.5/10)
The bottom line
After scoring all 41 clinics on our 4-criterion rubric (price & value, clinical oversight, medication options and transparency), Synergy RX (7.5/10) comes out ahead of He & She MD (7.3/10) — but the right choice still depends on what matters most to you.
Choose Synergy RX if you want best support — from $199/mo.
Visit Synergy RX →Choose He & She MD if you want this option — from $99/mo.
Visit He & She MD →Editor's overall pick
Not sold on either? Our highest-rated clinic overall is Wellorithm (8.3/10) from $147/mo — read the review →
Ready to start GLP-1 weight loss?
Our verdict for this matchup is Synergy RX.
Frequently asked questions
Which is better, Synergy RX or He & She MD?
Synergy RX scores higher overall (7.5/10 vs 7.3/10) and is our recommended pick for most people. If price is the priority, He & She MD starts at $99/mo.
How much does Synergy RX cost vs He & She MD?
Synergy RX is from $199/mo and He & She MD is from $99/mo. Both are typically cash-pay; HSA/FSA funds are often eligible. We run an automated check against each clinic's own live pricing page every week; a price left unconfirmed for 45 days shows as unverified rather than staying marked as current.
What is the difference between Synergy RX and He & She MD?
Synergy RX (7.5/10, #14 of 41) and He & She MD (7.3/10, #22 of 41) are scored independently across our 4 criteria: price & value, clinical oversight, medication options and transparency. See the detailed score breakdown above for the criterion-by-criterion comparison.
Does Synergy RX or He & She MD take insurance?
Neither Synergy RX nor He & She MD typically accepts insurance for GLP-1 weight-loss treatment. Both operate on a cash-pay model, though HSA and FSA funds are often eligible. Confirm at checkout.
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How we score: every clinic is rated on five weighted criteria from documented evidence. Prices checked weekly— see each review for that clinic's own verification status. Scores are never influenced by affiliate commissions. “Visit”/“Try” links may be affiliate links that support our work. Educational information only — not medical advice.