RxSpan MD vs Willow: Which GLP-1 Clinic Is Better in 2026?
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Short answer
RxSpan MD wins overall, scoring 7.3/10 vs 7.0/10 — mainly on transparency and price & value.
RxSpan MD wins overall, scoring 7.3/10 vs 7.0/10.
RxSpan MD
Both GLP-1 molecules in both routes plus three real brand names, and the most rigorously sourced medication-comparison page of any clinic we track — from a practice that publishes neither its pharmacy, nor the states it ships to, nor any refund terms behind a $2,327 upfront charge.
from $175/mo
Visit RxSpan MDWillow
Names 36 individual physicians and all five of its partner pharmacies — more clinical paper trail than anyone else here — but it is the most expensive clinic we rank, its advertised rate climbs to $549 as your dose goes up without saying so on the page, and it displays a 4.9 rating its own Trustpilot profile puts at 3.9.
from $299/mo
Visit WillowRxSpan MD vs Willow, side by side
| Feature | RxSpan MD | Willow |
|---|---|---|
| Our score | 7.3/10 | 7.0/10 |
| Starting price | $175/mo | $299/mo |
| Medication types | compounded semaglutide, compounded tirzepatide, oral semaglutide capsules, oral tirzepatide capsules, brand-name Ozempic/Wegovy/Zepbound | compounded semaglutide, compounded tirzepatide, oral semaglutide tablets, oral tirzepatide tablets, compounded semaglutide + tirzepatide tablet |
| Best for | — | — |
| Overall ranking | #15 | #22 |
| Price & Value (25%) | 6.0 | 5.5 |
| Clinical Oversight (30%) | 8.0 | 8.5 |
| Medication Options (20%) | 9.0 | 8.5 |
| Transparency (25%) | 6.5 | 5.5 |
Sources: RxSpan MD pricing verified on rxspanmd.com, Willow pricing verified on startwillow.com
Pros & cons
RxSpan MD
Pros
- + Semaglutide and tirzepatide in injection AND oral-capsule form, plus cash-pay Ozempic, Wegovy and Zepbound
- + Founding physician named and independently verifiable — Dr. John Diaz, MD, FACS, board-certified by the American Board of Plastic Surgery
- + Publishes the pre-discount rate next to the promo rate, and the full plan grid with the actual upfront dollar amount for each term
Cons
- − Weaker on Price & Value (6.0/10)
- − Weaker on Transparency (6.5/10)
- − Weaker on Clinical Oversight (8.0/10)
Willow
Pros
- + Names 36 US-licensed physicians with individual credentialed bio pages, and names all five partner pharmacies with full street addresses — no other clinic in this ranking does either
- + Month-to-month with no prepaid term: cancel by messaging support at least two calendar days before your refill processes, full refund before the prescription reaches the pharmacy
- + Two molecules in both routes — semaglutide and tirzepatide, weekly injection or daily oral dissolving tablet — plus a semaglutide/tirzepatide combination tablet nobody else here offers
Cons
- − Not available in 14 states
- − Weaker on Price & Value (5.5/10)
- − Weaker on Transparency (5.5/10)
The bottom line
After scoring all 30 clinics on our 4-criterion rubric (price & value, clinical oversight, medication options and transparency), RxSpan MD (7.3/10) comes out ahead of Willow (7.0/10) — but the right choice still depends on what matters most to you.
Choose RxSpan MD if you want this option — from $175/mo.
Visit RxSpan MD →Choose Willow if you want this option — from $299/mo.
Visit Willow →Editor's overall pick
Not sold on either? Our highest-rated clinic overall is Wellorithm (8.3/10) from $147/mo — read the review →
Ready to start GLP-1 weight loss?
Our verdict for this matchup is RxSpan MD.
Frequently asked questions
Which is better, RxSpan MD or Willow?
RxSpan MD scores higher overall (7.3/10 vs 7.0/10) and is our recommended pick for most people. RxSpan MD also has the lower starting price at $175/mo.
How much does RxSpan MD cost vs Willow?
RxSpan MD is from $175/mo and Willow is from $299/mo. Both are typically cash-pay; HSA/FSA funds are often eligible. We run an automated check against each clinic's own live pricing page every week; a price left unconfirmed for 45 days shows as unverified rather than staying marked as current.
What is the difference between RxSpan MD and Willow?
RxSpan MD (7.3/10, #15 of 30) and Willow (7.0/10, #22 of 30) are scored independently across our 4 criteria: price & value, clinical oversight, medication options and transparency. See the detailed score breakdown above for the criterion-by-criterion comparison.
Does RxSpan MD or Willow take insurance?
Neither RxSpan MD nor Willow typically accepts insurance for GLP-1 weight-loss treatment. Both operate on a cash-pay model, though HSA and FSA funds are often eligible. Confirm at checkout.
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How we score: every clinic is rated on five weighted criteria from documented evidence. Prices checked weekly— see each review for that clinic's own verification status. Scores are never influenced by affiliate commissions. “Visit”/“Try” links may be affiliate links that support our work. Educational information only — not medical advice.